EAHAD Factor VII Variant Database last updated on: 29/12/2020

Protein Structures available for Human Coagulation Factor VII

All structural analysis of the missense variants presented within this database uses active site-inhibited FVIIa in complex with soluble Tissue Factor (2A2Q) taken from the Protein Data Bank at RCSB (Bajaj et al., 2006, PMID: 16757484).


PDB Description In Complex with Resolution Chain Position PDBSum
1BF9 N-terminal EGF-like domain from human Factor VII - A
105-145
>>
1CVW Crystal structure of active site-inhibited human coagulation Factor VIIa (des-Gla) 2.2 H
L
213-466
150-204
>>
1DAN Complex of active site inhibited human blood coagulation Factor VIIa with human recombinant soluble Tissue Factor TF 2 H
L
213-466
61-212
>>
1DVA Crystal structure of the complex between the peptide exosite inhibitor e-76 and coagulation Factor VIIa exosite peptide 3 H/I
L/M
213-466
102-202
>>
1F7E The first EGF-like domain from human blood coagulation FVII - A
105-147
>>
1F7M The first EGF-like domain from human blood coagulation FVII - A
105-147
>>
1FAK Human Tissue Factor complexed with coagulation Factor VIIa inhibited with a bpti-mutant TF 2.1 H
L
213-466
61-212
>>
1FF7 The first EGF-like domain from human blood coagulation FVII (fucosylated at ser-60) - A
105-147
>>
1FFM The first EGF-like domain from human blood coagulation FVII (fucosylated at ser-60) - A
105-147
>>
1J9C Crystal structure of Tissue Factor-Factor VIIa complex TF 2.9 H
L
213-466
108-202
>>
1JBU Coagulation Factor VII zymogen (EGF2/protease) in complex with inhibitory exosite peptide a-183 exosite peptide 2 H
L
213-466
150-212
>>
1KLI CoFactor-and substrate-assisted activation of Factor VIIa 1.6 H
L
213-466
144-212
>>
1KLJ Crystal structure of uninhibited Factor VIIa 2.4 H
L
213-466
144-212
>>
1NL8 Theoretical model of the Tissue Factor/Factor VIIa/Factor xa complex TF - H
M
213-466
61-202
>>
1O5D Dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa) 2 H
L
213-466
61-212
>>
1QFK Structure of human Factor VIIa and its implications for the triggering of blood coagulation 2.8 H
L
213-466
109-212
>>
1W0Y TF7a_3771 complex - design of selective phenylglycine amide Tissue Factor/Factor VIIa inhibitors TF 2.5 H
L
213-466
61-202
>>
1W2K TF7a_4380 complex - design of selective phenylglycine amide Tissue Factor/Factor VIIa inhibitors TF 3 H
L
213-466
61-202
>>
1W7X Selective and orally bioavailable phenylglycine Tissue Factor/Factor VIIa inhibitors TF 1.8 H
L
213-466
150-204
>>
1W8B Selective and orally bioavailable phenylglycine Tissue Factor/Factor VIIa inhibitors TF 3 H
L
213-466
148-204
>>
1WQV Crystal structure of human Factor VIIa/Tissue Factor in complex with peptide mimetic inhibitor TF 2.5 H
L
213-466
61-212
>>
1WSS Human Factor VIIa-Tissue Factor in complex with peprid mimetic inhibitor that has two charge groups in p2 and p4 TF 2.6 H
L
213-466
61-212
>>
1WTG Human Factor VIIa-Tissue Factor complexed with ethylsulfonamide-d-biphenylalanine-gln-p-aminobenzamidine TF 2.2 H
L
213-466
61-212
>>
1WUN Human Factor VIIa-Tissue Factor complexed with ethylsulfonamide-d-trp-gln-p-aminobenzamidine TF 2.4 H
L
213-466
61-212
>>
1WV7 Human Factor VIIa-Tissue Factor complexed with ethylsulfonamide-d-5-propoxy-trp-gln-p-aminobenzamidine TF 2.7 H
L
213-466
61-212
>>
1YGC Short Factor VIIa with a small molecule inhibitor 2 H
L
213-466
150-212
>>
1Z6J Crystal structure of a ternary complex of Factor VIIa/Tissue Factor/pyrazinone inhibitor TF 2 H
L
213-466
61-202
>>
2A2Q Complex of Active-site Inhibited Human Coagulation Factor VIIa with Human Soluble Tissue Factor TF 1.8 H
L
213-466
61-212
>>
2AEI The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex TF 2.5 H
L
213-466
61-212
>>
2AER Crystal structure of benzamidine-Factor VIIa/soluble Tissue Factor complex TF 1.8 H
L
213-466
61-202
>>
2B7D Factor VIIa-Tissue Factor (FVIIa.TF) complex inhibitors TF 2.2 H
L
213-466
61-212
>>
2B8O Crystal structure of glu-gly-arg-chloromethyl ketone-Factor VIIa/soluble Tissue Factor complex TF 2.8 H
L
213-466
61-202
>>
2BZ6 Orally available Factor7a inhibitor 1.6 H
L
213-466
150-202
>>
2C4F The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex TF 1.7 H
L
213-466
61-202
>>
2EC9 Crystal structure analysis of human Factor VIIa 2 H
L
213-466
61-202
>>
2F9B Discovery of novel heterocyclic Factor VIIa inhibitors 2.5 H
L
213-466
61-212
>>
2FIR Crystal structure of dfpr-VIIa/sTF TF 2 H
L
213-466
61-202
>>
2FLB Novel 5-azaindole Factor VIIa inhibitors 1.9 H
L
213-466
61-212
>>
2FLR Human Factor VIIa-Tissue Factor complexed with benzylsulfonamide-d-ile-gln-p-aminobenzamidine TF 2.3 H
L
213-466
61-212
>>
2PUQ Human Factor VIIa-Tissue Factor complexed with highly selective peptide inhibitor TF 2 H
L
213-466
109-202
>>
2ZP0 Human Factor VIIa-Tissue Factor complexed with benzylsulfonamide-d-ile-gln-p-aminobenzamidine TF 2.7 H
L
213-466
61-212
>>
2ZWL Human Factor VIIa-Tissue Factor complexed with highly selective peptide inhibitor TF 2.2 H
L
213-466
61-212
>>
2ZZU Design and synthesis of peptidomimetic Factor VIIa inhibitors 2.5 H
L
213-466
61-212
>>
3ELA Crystal structure of active site inhibited coagulation Factor VIIa mutant in complex with soluble Tissue Factor TF 2.2 H
L
213-466
61-212
>>
3TH2 Gamma-carboxyglutamic acid (Gla) domains of vitamin k-dependent clotting Factors at physiological Ca2+ 1.7 H
L
213-466
61-202
>>
3TH3 Gamma-carboxyglutamic acid (Gla) domains of vitamin k-dependent clotting Factors at physiological Ca2+ 2.7 H
L
213-466
61-202
>>
3TH4 Gamma-carboxyglutamic acid (Gla) domains of vitamin k-dependent clotting Factors at physiological Ca2+ 1.8 H
L
213-466
61-202
>>
4IBL Rubidium Sites in Blood Coagulation Factor VIIa in complex with Tissue Factor TF 1.8 H
L
213-466
61-212
>>
4ISH Structure of FACTOR VIIA in complex with the inhibitor BMS-593214, a potent, selective FVIIa inhibitor hydrolase inhibitor 1.8 H
L
213-416
150-204
>>
4ISI Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors TF 1.9 H
L
213-466
150-204
>>
4JYU Nonbenzamidine acylsulfonamide Tissue Factor-Factor VIIa inhibitors TF 1.8 H
L
213-466
150-204
>>
4JYV Nonbenzamidine acylsulfonamide Tissue Factor-Factor VIIa inhibitors TF 2.1 H
L
213-466
150-204
>>
4JZD Nonbenzamidine acylsulfonamide Tissue Factor-Factor VIIa inhibitors TF 2.2 H
L
213-466
150-204
>>
4JZE Discovery of nonbenzamidine Factor VIIa inhibitors using a biaryl acid scaffold 1.5 H
L
213-466
150-204
>>
4JZF Discovery of nonbenzamidine Factor VIIa inhibitors using a biaryl acid scaffold 1.8 H
L
213-466
150-204
>>
4NA9 Tetrahydroquinoline derivatives as potent and selective Factor XIa inhibitors 2.2 H
L
213-466
150-204
>>
4NG9 Design and synthesis of phenylpyrrolidine phenylglycinamides as highly potent and selective TF-FVIIa inhibitors TF 2.2 H
L
213-466
150-204
>>
4NGA Design and synthesis of phenylpyrrolidine phenylglycinamides as highly potent and selective TF-FVIIa inhibitors TF 2.1 H
L
213-466
150-204
>>
4X8S Factor VIIa in complex with the inhibitor 4-bromo-2-methoxyphenol hydrolase inhibitor 2.1 H
L
213-466
150-204
>>
4X8T Factor VIIa in complex with the inhibitor 3Z8 hydrolase inhibitor 2.2 H
L
213-466
150-204
>>
4X8U Factor VIIa in complex with the inhibitor 3ZB hydrolase inhibitor 2.1 H
L
213-466
150-204
>>
4X8V Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening. hydrolase inhibitor 2.5 H
L
213-466
150-204
>>
4YT6 Factor VIIa in complex with the inhibitor 4JY hydrolase inhibitor 2.0 H
L
213-466
148-204
>>
4YT7 Factor VIIa in complex with the inhibitor 4K1 hydrolase inhibitor 2.3 H
L
213-466
148-204
>>
4ZXX Factor VIIa in complex with 4T0 Inhibitor hydrolase inhibitor 2.6 H
L
213-466
150-204
>>
4ZXY Factor VIIa in complex with 4T1 Inhibitor hydrolase inhibitor 2.0 H
L
213-466
150-204
>>