Protein Structures available for Human Coagulation Factor VII
All structural analysis of the missense variants presented within this database uses active site-inhibited FVIIa in complex with soluble Tissue Factor (2A2Q) taken from the Protein Data Bank at RCSB (Bajaj et al., 2006, PMID: 16757484).
| PDB | Description | In Complex with | Resolution | Chain | Position | PDBSum |
|---|---|---|---|---|---|---|
| 1BF9 | N-terminal EGF-like domain from human Factor VII | - | A |
105-145 |
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| 1CVW | Crystal structure of active site-inhibited human coagulation Factor VIIa (des-Gla) | 2.2 | H L |
213-466 150-204 |
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| 1DAN | Complex of active site inhibited human blood coagulation Factor VIIa with human recombinant soluble Tissue Factor | TF | 2 | H L |
213-466 61-212 |
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| 1DVA | Crystal structure of the complex between the peptide exosite inhibitor e-76 and coagulation Factor VIIa | exosite peptide | 3 | H/I L/M |
213-466 102-202 |
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| 1F7E | The first EGF-like domain from human blood coagulation FVII | - | A |
105-147 |
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| 1F7M | The first EGF-like domain from human blood coagulation FVII | - | A |
105-147 |
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| 1FAK | Human Tissue Factor complexed with coagulation Factor VIIa inhibited with a bpti-mutant | TF | 2.1 | H L |
213-466 61-212 |
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| 1FF7 | The first EGF-like domain from human blood coagulation FVII (fucosylated at ser-60) | - | A |
105-147 |
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| 1FFM | The first EGF-like domain from human blood coagulation FVII (fucosylated at ser-60) | - | A |
105-147 |
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| 1J9C | Crystal structure of Tissue Factor-Factor VIIa complex | TF | 2.9 | H L |
213-466 108-202 |
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| 1JBU | Coagulation Factor VII zymogen (EGF2/protease) in complex with inhibitory exosite peptide a-183 | exosite peptide | 2 | H L |
213-466 150-212 |
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| 1KLI | CoFactor-and substrate-assisted activation of Factor VIIa | 1.6 | H L |
213-466 144-212 |
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| 1KLJ | Crystal structure of uninhibited Factor VIIa | 2.4 | H L |
213-466 144-212 |
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| 1NL8 | Theoretical model of the Tissue Factor/Factor VIIa/Factor xa complex | TF | - | H M |
213-466 61-202 |
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| 1O5D | Dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa) | 2 | H L |
213-466 61-212 |
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| 1QFK | Structure of human Factor VIIa and its implications for the triggering of blood coagulation | 2.8 | H L |
213-466 109-212 |
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| 1W0Y | TF7a_3771 complex - design of selective phenylglycine amide Tissue Factor/Factor VIIa inhibitors | TF | 2.5 | H L |
213-466 61-202 |
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| 1W2K | TF7a_4380 complex - design of selective phenylglycine amide Tissue Factor/Factor VIIa inhibitors | TF | 3 | H L |
213-466 61-202 |
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| 1W7X | Selective and orally bioavailable phenylglycine Tissue Factor/Factor VIIa inhibitors | TF | 1.8 | H L |
213-466 150-204 |
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| 1W8B | Selective and orally bioavailable phenylglycine Tissue Factor/Factor VIIa inhibitors | TF | 3 | H L |
213-466 148-204 |
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| 1WQV | Crystal structure of human Factor VIIa/Tissue Factor in complex with peptide mimetic inhibitor | TF | 2.5 | H L |
213-466 61-212 |
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| 1WSS | Human Factor VIIa-Tissue Factor in complex with peprid mimetic inhibitor that has two charge groups in p2 and p4 | TF | 2.6 | H L |
213-466 61-212 |
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| 1WTG | Human Factor VIIa-Tissue Factor complexed with ethylsulfonamide-d-biphenylalanine-gln-p-aminobenzamidine | TF | 2.2 | H L |
213-466 61-212 |
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| 1WUN | Human Factor VIIa-Tissue Factor complexed with ethylsulfonamide-d-trp-gln-p-aminobenzamidine | TF | 2.4 | H L |
213-466 61-212 |
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| 1WV7 | Human Factor VIIa-Tissue Factor complexed with ethylsulfonamide-d-5-propoxy-trp-gln-p-aminobenzamidine | TF | 2.7 | H L |
213-466 61-212 |
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| 1YGC | Short Factor VIIa with a small molecule inhibitor | 2 | H L |
213-466 150-212 |
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| 1Z6J | Crystal structure of a ternary complex of Factor VIIa/Tissue Factor/pyrazinone inhibitor | TF | 2 | H L |
213-466 61-202 |
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| 2A2Q | Complex of Active-site Inhibited Human Coagulation Factor VIIa with Human Soluble Tissue Factor | TF | 1.8 | H L |
213-466 61-212 |
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| 2AEI | The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex | TF | 2.5 | H L |
213-466 61-212 |
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| 2AER | Crystal structure of benzamidine-Factor VIIa/soluble Tissue Factor complex | TF | 1.8 | H L |
213-466 61-202 |
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| 2B7D | Factor VIIa-Tissue Factor (FVIIa.TF) complex inhibitors | TF | 2.2 | H L |
213-466 61-212 |
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| 2B8O | Crystal structure of glu-gly-arg-chloromethyl ketone-Factor VIIa/soluble Tissue Factor complex | TF | 2.8 | H L |
213-466 61-202 |
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| 2BZ6 | Orally available Factor7a inhibitor | 1.6 | H L |
213-466 150-202 |
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| 2C4F | The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex | TF | 1.7 | H L |
213-466 61-202 |
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| 2EC9 | Crystal structure analysis of human Factor VIIa | 2 | H L |
213-466 61-202 |
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| 2F9B | Discovery of novel heterocyclic Factor VIIa inhibitors | 2.5 | H L |
213-466 61-212 |
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| 2FIR | Crystal structure of dfpr-VIIa/sTF | TF | 2 | H L |
213-466 61-202 |
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| 2FLB | Novel 5-azaindole Factor VIIa inhibitors | 1.9 | H L |
213-466 61-212 |
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| 2FLR | Human Factor VIIa-Tissue Factor complexed with benzylsulfonamide-d-ile-gln-p-aminobenzamidine | TF | 2.3 | H L |
213-466 61-212 |
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| 2PUQ | Human Factor VIIa-Tissue Factor complexed with highly selective peptide inhibitor | TF | 2 | H L |
213-466 109-202 |
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| 2ZP0 | Human Factor VIIa-Tissue Factor complexed with benzylsulfonamide-d-ile-gln-p-aminobenzamidine | TF | 2.7 | H L |
213-466 61-212 |
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| 2ZWL | Human Factor VIIa-Tissue Factor complexed with highly selective peptide inhibitor | TF | 2.2 | H L |
213-466 61-212 |
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| 2ZZU | Design and synthesis of peptidomimetic Factor VIIa inhibitors | 2.5 | H L |
213-466 61-212 |
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| 3ELA | Crystal structure of active site inhibited coagulation Factor VIIa mutant in complex with soluble Tissue Factor | TF | 2.2 | H L |
213-466 61-212 |
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| 3TH2 | Gamma-carboxyglutamic acid (Gla) domains of vitamin k-dependent clotting Factors at physiological Ca2+ | 1.7 | H L |
213-466 61-202 |
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| 3TH3 | Gamma-carboxyglutamic acid (Gla) domains of vitamin k-dependent clotting Factors at physiological Ca2+ | 2.7 | H L |
213-466 61-202 |
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| 3TH4 | Gamma-carboxyglutamic acid (Gla) domains of vitamin k-dependent clotting Factors at physiological Ca2+ | 1.8 | H L |
213-466 61-202 |
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| 4IBL | Rubidium Sites in Blood Coagulation Factor VIIa in complex with Tissue Factor | TF | 1.8 | H L |
213-466 61-212 |
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| 4ISH | Structure of FACTOR VIIA in complex with the inhibitor BMS-593214, a potent, selective FVIIa inhibitor | hydrolase inhibitor | 1.8 | H L |
213-416 150-204 |
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| 4ISI | Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors | TF | 1.9 | H L |
213-466 150-204 |
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| 4JYU | Nonbenzamidine acylsulfonamide Tissue Factor-Factor VIIa inhibitors | TF | 1.8 | H L |
213-466 150-204 |
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| 4JYV | Nonbenzamidine acylsulfonamide Tissue Factor-Factor VIIa inhibitors | TF | 2.1 | H L |
213-466 150-204 |
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| 4JZD | Nonbenzamidine acylsulfonamide Tissue Factor-Factor VIIa inhibitors | TF | 2.2 | H L |
213-466 150-204 |
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| 4JZE | Discovery of nonbenzamidine Factor VIIa inhibitors using a biaryl acid scaffold | 1.5 | H L |
213-466 150-204 |
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| 4JZF | Discovery of nonbenzamidine Factor VIIa inhibitors using a biaryl acid scaffold | 1.8 | H L |
213-466 150-204 |
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| 4NA9 | Tetrahydroquinoline derivatives as potent and selective Factor XIa inhibitors | 2.2 | H L |
213-466 150-204 |
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| 4NG9 | Design and synthesis of phenylpyrrolidine phenylglycinamides as highly potent and selective TF-FVIIa inhibitors | TF | 2.2 | H L |
213-466 150-204 |
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| 4NGA | Design and synthesis of phenylpyrrolidine phenylglycinamides as highly potent and selective TF-FVIIa inhibitors | TF | 2.1 | H L |
213-466 150-204 |
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| 4X8S | Factor VIIa in complex with the inhibitor 4-bromo-2-methoxyphenol | hydrolase inhibitor | 2.1 | H L |
213-466 150-204 |
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| 4X8T | Factor VIIa in complex with the inhibitor 3Z8 | hydrolase inhibitor | 2.2 | H L |
213-466 150-204 |
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| 4X8U | Factor VIIa in complex with the inhibitor 3ZB | hydrolase inhibitor | 2.1 | H L |
213-466 150-204 |
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| 4X8V | Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening. | hydrolase inhibitor | 2.5 | H L |
213-466 150-204 |
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| 4YT6 | Factor VIIa in complex with the inhibitor 4JY | hydrolase inhibitor | 2.0 | H L |
213-466 148-204 |
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| 4YT7 | Factor VIIa in complex with the inhibitor 4K1 | hydrolase inhibitor | 2.3 | H L |
213-466 148-204 |
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| 4ZXX | Factor VIIa in complex with 4T0 Inhibitor | hydrolase inhibitor | 2.6 | H L |
213-466 150-204 |
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| 4ZXY | Factor VIIa in complex with 4T1 Inhibitor | hydrolase inhibitor | 2.0 | H L |
213-466 150-204 |
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